Summary

For a list of publications, go here.

OverviewGraphic

 We live at the center.

GoldFlask

We’re special! We run our reactions in gold-plated flasks!
(Confession: When the above happens, it means the reaction didn’t work.)

Synthetic targets serve as a driving force for the continued improvement of current methodologies, and in turn, synthetic methodologies often find application in targets for which they were not specifically designed.  At the heart of this synergy, is a mechanistic understanding of reactions, which facilitates reaction optimization and application.

Homogeneous gold(I) catalysts have emerged as powerful reagents for activating unsaturated hydrocarbons (π-systems) toward nucleophilic addition and involvement in selective skeletal rearrangements. The products of these reactions are important building blocks in syntheses of pharmaceuticals and materials; however, the mechanisms of these processes are not fully understood.  Our work is focused on the examination of structure, formation, and reactivity of gold complexes including a detailed exploration of ligand effects on the kinetics and stability of reactive intermediates relevant to catalysis.  The information we obtain will be used to improve the scope, catalytic efficiency, and cost-effectiveness of gold(I) catalysts, thus expanding chemists synthetic capabilities.

KatarinaBox-Back

Members of our research group will obtain extensive experience in NMR spectroscopy (heteronuclear, variable temperature), organometallic and organic synthesis, handling of air-sensitive compounds, and physical organic techniques.

We traded with Dr. Bierbach; a bench from our lab (he needed space) got us a glovebox from his lab. I think we got the better end of that deal! Thanks Dr. Bierbach!